Effect of typical and atypical anxiolytics on the behavior and electrophysiological parameters of rats with model cerebrovascular pathology
Molodavkin, G.M.; Cadikov, M.K.; Voronina, T.A.; Sadikova, Z.U.; Meletova, O.K.; Pchelkina, M.I.; Larentsova, L.I.; Gan'shina, T.S.; Mirzoian, R.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 67(6): 16-19
2004
ISSN/ISBN: 0869-2092 PMID: 15707007 Document Number: 583636
The influence a series of anxiolytics (tranquilizers) on behavioral disturbances was studied in outbread white male rats with cerebrovascular pathology modeled by ligation of common carotid arteries. All studied anxiolytics (diazepam, buspirone, mexidol) exhibited more of less pronounced protective action with respect to the pathology studied. The most significant protective effect was produced by the atypical anxiolytic mexidol. Special features of the effect of mexidol are probably explained by combination of several effects (anxiolytic, nootrope, antioxidant, and antihypoxant). in the pharmacological activity spectrum of this drug.