The animal model of anxious depression: persistence of behavior pathology
Avgustinovich, D.F.; Kovalenko, I.L.; Kudriavtseva, N.N.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 90(10): 1235-1245
2004
ISSN/ISBN: 0869-8139 PMID: 15628180 Document Number: 577060
It has been shown that chronic psychoemotional stress caused by repeated experience of defeats in agonistic interactions during 30 days led to development of the anxiety depression--like state accompanied by pronounced anxiety, behavioral deficit, decreased communication, and increased depressiveness as estimated by various behavioral tests in male mice. This psychopathological state still existed after 1-2 weeks living with females in comfortable conditions (without confrontations with other males), that testified to persistence of behavior pathology.