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Effect of preliminary administration of allogenic cells on transplantation immunity in mice receiving cyclophosphamide

Cherniakhovskaia, I.I.; Fontalin, L.N.; Rubakova, E.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 85(2): 192-194

1978

ISSN/ISBN: 0365-9615
PMID: 564721
Document Number: 135771
It was shown that injection of 1 X 10(8) spleen cells from C57Bl/6 mice to CBA mice one day before the injection of cyclophosphamide (CY) helped the take of 2 X 10(7) allogeneic or semiallogeneic cells (injected for the second time 3 to 6 hours after C)). Criterion of survival is the ability of the donor cells to produce antibodies to sheep red blood cells in the recipients tolerant of this antigen. Injection of 1 X 10(8) allogeneic cells two days before CY produces no protective effect. Killer-cells proved to appear on the second day after the immunization with allogeneic cells; their peak was reached on the 5th day. The data obtained suggest that CY eliminated the recipients' lymphocytes, which responded to the transplantation antigens, whereas the killer-cells already formed were stable to the CY action.

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Babadzhanov, A.S.; Slavina, E.G. 1983: Effect of preliminary administration of cyclophosphamide and pretransplantation irradiation on the growth of syngeneic tumors in mice Biulleten' Eksperimental'noi Biologii i Meditsiny 95(1): 84-86
Pauluzzi, S.; Merletti, L. 1977: Effect of cyclophosphamide on syngeneic transplantation of adenovirus 12-transformed tumor cells in C3H/he mice Bollettino dell'Istituto Sieroterapico Milanese 56(4): 310-315
Li, Y.; Newby, S.A.; Johnston, J.V.; Hellström, K.E.; Chen, L. 1995: Protective immunity induced by B7/CD28-costimulated gamma delta T cells to the EL-4 lymphoma in allogenic athymic mice Journal of Immunology 155(12): 5705-5710
Brondz, B.D.; Kotomina, I.F. 1973: Origin of effector and rosette-forming cells in transplantation immunity in mice Biulleten' Eksperimental'noi Biologii i Meditsiny 76(9): 69-72
Wietrzyk, J.; Opolski, A.; Madej, J.; Radzikowski, C. 2000: Antitumour and antimetastatic effect of genistein alone or combined with cyclophosphamide in mice transplanted with various tumours depends on the route of tumour transplantation In Vivo 14(2): 357-362
Li, S.E.; Ivanets, T.A.; Turchenko, G.V. 1985: Changes in the immunity indices of intact and partially hepatectomized mice undergoing the transplantation of splenic cells from hypokinetic donors Biulleten' Eksperimental'noi Biologii i Meditsiny 99(4): 464-465
Naito, K.; Pellis, N.R.; Kahan, B.D. 1988: Effect of continuous administration of interleukin 2 on active specific chemoimmunotherapy with extracted tumor-specific transplantation antigen and cyclophosphamide Cancer Research 48(1): 101-108
Machnicka, B.; Golińska, Z.; Bany, J. 1979: The influence of cyclophosphamide on immunity in mice infected with Trichinella spiralis Wiadomosci Parazytologiczne 25(5): 505-517
Gutstein, N.L.; Wofsy, D. 1986: Administration of F(ab')2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells Journal of Immunology 137(11): 3414-3419
Contassot, E.; Ferrand, C.; Angonin, R.; Cohen, J.L.; de Carvalho Bittencourt, M.; Lorchel, F.; Laithier, V.; Cahn, J.Y.; Klatzmann, D.; Herve, P.; Tiberghien, P. 2000: Ganciclovir-sensitive acute graft-versus-host disease in mice receiving herpes simplex virus-thymidine kinase-expressing donor T cells in a bone marrow transplantation setting Transplantation 69(4): 503-508
Chen, T.L.; Passos-Coelho, J.L.; Noe, D.A.; Kennedy, M.J.; Black, K.C.; Colvin, O.M.; Grochow, L.B. 1995: Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation Cancer Research 55(4): 810-816
Antonenko, V.T.; Chornen'ka, V.D. 1977: Participation of lymphoid organ T- and B-lymphocytes in transplantation immunity in immune deficiency modeled with anti-thymus serum and cyclophosphamide Fiziolohichnyi Zhurnal 23(6): 733-740
Palmer, D.W.; Dauphinée, M.J.; Murphy, E.; Talal, N. 1976: Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells Clinical and Experimental Immunology 23(3): 578-581
Dreger, P.; Glass, B.; Uharek, L.; Zeis, M.; Schmitz, N. 1997: Allogenic transplantation of mobilized peripheral blood progenitor cells: towards tailored cell therapy International Journal of Hematology 66(1): 1-11
Maianskiĭ, D.N.; Makarov, M.G. 1972: The immunomorphology of lymphoid organs and the liver following transplantation of allogenic spleen cells into immunologically immature recipients Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 49(8): 121-127
Palmas, C.; Ecca, A.R.; Gabriele, F. 1993: Specific cross-immunity between Hymenolepis nana and H. diminuta: effects of transfer of immunity with homologous and heterologous immune mesenteric lymph node cells in BALB/c mice Parassitologia 35(1-3): 73-76
Boyer, C.M.; Kreider, J.W.; Bartlett, G.L. 1982: Regulation of the expression of adoptive tumor rejection immunity by recipient cyclophosphamide-sensitive cells Cancer Research 42(6): 2211-2215
Lackovic, V.; Borecký, L. 1979: Production of antiviral and migration inhibitory activities in the peritoneum of mice after inoculation with allogenic Ehrlich ascites tumor cells Acta Biologica et Medica Germanica 38(5-6): 781-789
Athanassakis, I.; Vassiliadis, S. 1995: Effect of IFN-gamma administration in virgin and pregnant mice: distribution of lymphoid and myeloid cells in the spleen European Cytokine Network 6(3): 167-176
Harada, M.; Omoto, K.; Kimura, G.; Nomoto, K. 1995: Priming with donor spleen cells and activated B cells can induce prolonged survival of class I-disparate skin allografts in cyclophosphamide-treated mice Transplantation 60(5): 517-519