Hyperactive T-cell function in young NZB mice; increased proliferative responses to allogenic cells
Palmer, D.W.; Dauphinée, M.J.; Murphy, E.; Talal, N.
Clinical and Experimental Immunology 23(3): 578-581
1976
ISSN/ISBN: 0009-9104 PMID: 133009 Document Number: 103885
The one-way mixed lymphocyte reaction was employed to study proliferative responses to antigens by mature, immunocompetent T cells from NZB mice 3 weeks to 4 months old. Compared to cells from control mice of the same H-2 type, thymus, spleen and lymph node cells from NZB mice were hyperactive in this response. The results are discussed in relation to possible effects of chronic stimulation by endogenous type C leukaemia virus upon differentiation of functional T cells or upon regulation by T cells of other T-cell functions, including augmentation of antibody responses.