Immunoregulatory T cells in measles. the relationship between reduced lymphocyte proliferative response to PHA and increased proportion of circulating suppressor-cytotoxic T cells
Bertotto, A.; Rambotti, A.; Gentilini, F.; Stefanelli, M.; Zucchetti, P.; Vaccaro, R.
Microbiologica 7(1): 21-27
1984
ISSN/ISBN: 0391-5352 PMID: 6233473 Document Number: 224872
Viral infections are often associated with immunodeficiency states. Although T lymphocytes have been thought to suppress the host's immune response, the precise cellular basis for this phenomenon remains unclear. Therefore, we characterized peripheral blood mononuclear cells from 9 measles virus-infected children by means of monoclonal antibodies directed against surface antigens expressed on human T lymphocytes and T-cell subsets. In addition, the measles lymphocyte blast transformation response to the T-cell mitogen phytohaemagglutinin (PHA) was evaluated as an index of specific T-cell immunocompetence. During the course of measles, there was a slight reduction in the proportion of total circulating T cells, with a relative decrease in helper-inducer and a parallel increase in suppressor-cytotoxic T lymphocytes. The PHA lymphocyte blastogenic response was found to be defective in children with measles and, interestingly, there was a significant negative correlation between the reduced PHA blast transformation value and the increased proportion of suppressor-cytotoxic cells. The biological implications of these finding with respect to the underlying immunopathology of the measles virus infection are discussed.