Allogenic transplantation of mobilized peripheral blood progenitor cells: towards tailored cell therapy
Dreger, P.; Glass, B.; Uharek, L.; Zeis, M.; Schmitz, N.
International Journal of Hematology 66(1): 1-11
1997
ISSN/ISBN: 0925-5710 PMID: 9220655 Document Number: 481638
Mobilized peripheral blood progenitor cells (PBPC) are increasingly being used instead of bone marrow for allogeneic transplantation. The present article will briefly review important aspects of allogeneic PBPCT including donor safety, timing of leukapheresis, factors influencing the yield, cellular composition of PBPC allografts, hematopoietic capacity of allogeneic PBPC, and graft-versus-host and graft-versus-leukemia activities. It will particularly focus on the perspectives opened by PBPC for graft engineering and cell therapy.
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