Prostacyclin: a potent activator of human colonic adenylate cyclase activity
Simon, B.; Kather, H.; Kommerell, B.
Zeitschrift für Gastroenterologie 16(12): 748-751
1978
ISSN/ISBN: 0044-2771 PMID: 369163 Document Number: 133804
Prostacyclin and its stable catabolite 6-keto-prostaglandin F1 alpha were tested on the human colonic mucosal adenylate cyclase which represents the key enzyme in the secretory process in this organ. Prostacyclin was able to activate dose-dependently the human cyclase system. Saturating concentrations of prostacyclin and 6-keto-prostaglandin F1 alpha (each 0.28 mM) increased the enzyme activity 2.5-fold and only 1.4-fold, respectively. The presence of prostacyclin receptor sites in human colonic mucosa suggests a physiological role of this novel prostaglandin in human colonic function.