Lithium inhibition of the adenosine-induced increase of adenylate cyclase activity
Ebstein, R.P.; Reches, A.; Belmaker, R.H.
Journal of Pharmacy and Pharmacology 30(2): 122-123
1978
ISSN/ISBN: 0022-3573 PMID: 24099 Document Number: 135674
Adenosine has been shown to stimulate accumulation of cyclic(c)AMP in brain tissue. The precise function of adenosine in the CNS is still unclear, although the available evidence would suggest a general modulatory role in regulating neural transmission in several different brain areas. The increasing importance attributed to adenosine in central neurotransmission prompted examination of the effect of Li.
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