Adenylate cyclase and guanylate cyclase activity in the isolated kidney glomerulus of the rat
Sraer, J.D.; Wolff, M.; Delarue, F.; Sraer, J.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 173(2): 445-452
1979
ISSN/ISBN: 0037-9026 PMID: 41622 Document Number: 142699
Isolated rat renal glomeruli contain an adenylate cyclase system and guanylate cyclase system. Adenylate cyclase was strikingly activated by purified parathyroid hormone, epinephrine, prostaglandin I2 and histamine. The demonstration of PTH activated adenylate cyclase in glomeruli raises the possibility of a role of this hormone in regulation of glomerular filtration rate. Guanylate cyclase was strikingly activated by CA2+, nitrate derivatives such as sodium nitroprusside. Its role remained still unknown.