The attenuation of epinephrine-dependent adenylate cyclase by adenosine and the characteristics of the adenosine stimulatory and inhibitory sites
Braun, S.; Levitzki, A.
Molecular Pharmacology 16(3): 737-748
1979
ISSN/ISBN: 0026-895X PMID: 530257 Document Number: 139520
Turkey erythrocyte and rat caudate nucleus adenylate cyclase AMP production. The caudate nucleus adenylate cyclase presents a diametrically opposite situation where adenosine is a more potent agonist than epinephrine and thus, in the presence of adenosine, cAMP production is increased above that achieved by .beta.-agonists. Caudate nucleus cyclase but not turkey erythrocyte cyclase possesses also an adenosine inhibitory site distinct from the stimulatory site. The ligand specificities of these 2 types of adenosine sites are different. The possible physiological role of the adenosine-induced modulation of hormonal response is discussed.