Clinical immunological observations of persons in a period of prolonged hypokinesia and the readaptation thereafter
Dygin, V.P.; Maksimov, V.A.; Shubin, V.G.; Sverdlina, N.T.; Leshchenko, N.M.
Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 12(5): 46-50
1978
ISSN/ISBN: 0321-5040 PMID: 692070 Document Number: 133555
To study the role of autoimmune processes in the origin of changes occurring during prolonged bed rest, 9 young male test subjects were examined during 30 day and 21-49 day bed rest experiments and recovery periods. No antibodies to antigens of the heart, liver and kidneys were found. Ten of 21 test subjects at the end of bed rest and 12 test subjects during recovery showed a high titer of the circulating cardiac antigen. Electro-, mechano-, and polycardiographic studies demonstrated that the subjects with the circulating cardiac antigen displayed more marked changes in the ECG T-wave and the contractile function of the myocardium. These changes were accompanied by activation of the enzymes alanine-aminotransferase, aspartate-aminotransferase and lactate dehydrogenase.