Frequency of lethal chromosomal and genome mutations in man
Kuleshov, N.P.
Tsitologiia i Genetika 12(1): 57-63
1978
ISSN/ISBN: 0564-3783 PMID: 567394 Document Number: 129930
The chromosome anomaly frequency in 209 children who died in the perinatal period was 7.2%. These cases were found to consist of 8 autosome trisomies, 5 anomalies in sex chromosome system, 1 case of triploidy and 1 case of structural reorganization. Accounting for the elimination of chromosome anomalies during the early periods of fetus development, the frequency of chromosome lethals was shown to be 6.44 .times. 10-2 in registered pregnancies and 54.89 .times. 10-2 in conceptions.