Human-pharmacological investigations on the platelet adhesiveness- and aggregation-inhibiting effect of EMD 26 644, an oxazolyl-thio-propionic acid derivate
Jacobi, E.; Leopold, G.; Lissner, R.; Maisenbacher, J.
International Journal of Clinical Pharmacology and Biopharmacy 16(3): 136-141
1978
ISSN/ISBN: 0340-0026 PMID: 649232 Document Number: 129685
EMD 26 644, a compound of novel chemical structure and with platelet aggregation-inhibiting properties, was investigated in 2 controlled clinical pharmacological studies involving 42 normal volunteers. In the first study with 22 subjects exhibiting normal or spontaneously increased platelet aggregation the influence of 1 X 250 mg EMD 26 644 p.o. on the platelet aggregation and adhesiveness was examined ex vivo. In the second study 20 subjects with and without a premedication of 1 X 250 mg EMD 26 644 were exposed an artificial climate with special platelet-irritating properties. A single oral dose of 250 mg EMD 26 644 markedly and significantly inhibited the platelet aggregation and adhesiveness over a period of several days.