Derivatives of imidazo[1,2-c]quinazoline with inhibiting effect on platelet aggregation
Cardellini, M.; Franchetti, P.; Grifantini, M.; Martelli, S.; Petrelli, F.
Il Farmaco; Edizione Scientifica 30(7): 536-546
1975
ISSN/ISBN: 0430-0920 PMID: 1149881 Document Number: 87835
Several 5-monosubstituted and 5,5-disubstituted 5,6-dihydroimidazo[1,2-c]quinazolines were synthesized in high yields by the condensation of 2-(o-aminophenyl)imidazole with the required aliphatic or aromatic aldehydes or ketones. Some of these compounds caused inhibition of ADP-induced platelet aggregation in vitro at concentration of 10(-5) to 10(-4) M. The structure-activity relationships of these inhibitors are discussed.