Synthesis and inhibitory effects of 1,4,5-trialkyl-2-thioimidazole derivatives on platelet aggregation
Fatimi, J.; Lagorce, J.F.; Chabernaud, M.L.; Buxeraud, J.; Raby, C.
Bollettino Chimico Farmaceutico 133(3): 151-155
1994
ISSN/ISBN: 0006-6648 PMID: 8011274 Document Number: 434225
New 1,4,5-trialkyl-2-thioimidazole have been synthesized by the condensation of alpha-hydroxyketones and alkylthioureas. The in vitro platelet aggregation inhibiting effect of prepared compounds on human platelets was studied in the presence of ADP and collagen as inducers. The formation of thromboxane B2(TXB2) was inhibited. 1-isopropyl-4,5-dimethyl-2-thioimidazole has the greatest aggregation inhibiting effect, about 4 times that of aspirin. It highly inhibits the production of TXB2 (68.5% for a final concentration of 0.04 M).