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Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators?

Simon, M.F.; Chap, H.; Douste-Blazy, L.

Biochemical and Biophysical Research Communications 108(4): 1743-1750

1982

ISSN/ISBN: 0006-291X
PMID: 6924857
Document Number: 194803
Four ether analogs of lysophosphatidic acids (LPA) were prepared. They include 1-hexadecyl-sn-glyceryl-3-phosphate (1-Hx-GPA), 1-hexadecyl-2-acetyl-sn-glyceryl-3-phosphate (1-Hx-2-Ac-GPA) and their respective enantiomers. The 4 compounds promoted human platelet aggregation. 1-Hx-GPA was 10 times less potent than platelet activating factor (PAF-acether), but 30 times more powerful than 1-palmitoyl-sn-glyceryl-3-phosphate (1-P-GPA). The 4 compounds did not display any strong stereospecificity and acetylation of the 2-hydroxyl-group was not essential for full activity. They all displayed specific platelet desensitization to 1-Hx-GPA, but not to PAF-acether. Evidently, ether analogs of LPA represent a new group of powerful phospholipid mediators acting by a mechanism in some way different from that of PAF-acether.

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