The effect of calcitonin on secretin-stimulated pancreatic secretion in man
Odes, H.S.; Barbezat, G.O.; Clain, J.E.; Bank, S.
South African Medical Journal 53(6): 201-203
1978
ISSN/ISBN: 0256-9574 PMID: 653509 Document Number: 129379
The effect of calcitonin on pancreatic secretion was studied in man. After steady-state secretion had been achieved with a constant intravenous infusion of secretin (2 microgram/kg/h), either calcitonin (0,16 and 0,32 microgram/kg/h) or 0,15M NaCl was infused over a period of 80 minutes. Calcitonin did not affect pancreatic volume output or bicarbonate concentration, but amylase concentration and output were significantly inhibited (P less than 0.025). The colour index in the duodenal juice was unchanged by calcitonin. No changes were observed in blood glucose or serum calcium concentrations.