Comparison of secretin and vasoactive intestinal peptide on pancreatic secretion in dogs
Konturek, S.J.; Thor, P.; Dembinski, A.; Krol, R.
Gastroenterology 68(6): 1527-1535
1975
ISSN/ISBN: 0016-5085 PMID: 1132634 Document Number: 88619
Vasoactive inhibitory peptide (VIP) and secretin were compared in regard to the stimulation of pancreatic bicarbonate secretion and the augmentation of pancreatic response to caerulein or a peptone meal in dogs with chronic gastric and pancreatic fistulae. Dose-response analysis showed that maximal bicarbonate response to VIP was about 17% of that to secretin Both caerulein and endogenous cholecystokinin, released by a peptone meal, clearly potentiated pancreatic bicarbonate response to VIP in a manner similar to secretin The interactions of those two peptides showed that VIP is a potent inhibitor of secretin-induced pancreatic secretion. From the dose-response curve to secretin alone and with VIP, Michaelis-Menten analysis showed typical competitive inhibition, which indicated that VIP and secretin shared a common receptor site.