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Vasoactive intestinal peptide stimulates the growth of rat hepatoma cells in vitro

Huang, X.; Zhang, Y.; Bu, Y.; Su, H.

Chinese Medical Sciences Journal 8(3): 147-150

1993

ISSN/ISBN: 1001-9294
PMID: 8142629
Document Number: 418265
Using tetrazolium colorimetric assay (MTT assay) and cell counting methods, the effect of vasoactive intestinal peptide (VIP) on the growth of cultured rat hepatoma FSK-7902 cells was investigated. The results showed that VIP obviously stimulated the proliferation of the rat hepatoma cells. The growth promoting effect increased with VIP concentration. Exposure to VIP for 12 h followed by removal of the peptide resulted in sustained growth promotion for several days.

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