An experimental study of the effect of the posterior and celiac branches on the secretion of pancreatic glucagon, insulin, gastrin and secretin
Tamiya, Y.
Nihon Geka Gakkai Zasshi 85(3): 244-253
1984
ISSN/ISBN: 0301-4894 PMID: 6381987 Document Number: 222343
Effects of electrical stimulation to the posterior (P-S) and celiac (C-S) branches of the abdominal vagus on the secretion of pancreatic glucagon (GI), insulin (IRI), gastrin (IRG) and secretion (IRS) were studied in anesthetized mongrel dogs. Following P-S and C-S, plasma concentration of GI and IRI increased without any changes of blood flow in the cranial pancreaticoduodenal vein. The similar responses shown in their magnitudes and timing would indicate that the output of the hormones were accelerated by both branches to the same extent and subsequently the effect of the posterior branch was caused via the celiac one. Plasma concentration of GI and IRI in the portal vein increased was elevated following P-S, but remained unchanged following C-S. these data would account for that an increase in portal blood flow exceeded relatively that of the output of the hormones following C-S. Portal plasma concentration of IRG increased following P-S and this would be due to the accelerated production of antral gastrin via the posterior antral branches. No response shown following C-S would reveal that an increase of portal blood flow exceeded over the production of extragastric gastrin via the celiac branch. Portal plasma concentration of IRS remained unchanged following P-S, but decreased following C-S. However, as these results were strongly influenced by changes of portal blood flow, the effect of both branches on pancreatic secretion needed further investigation with blood flow measurement.