Effect of long-term phenytoin treatment on the levels of calcium and magnesium in rat femurs
Maurat, J.P.; Bugnon, C.; Rousselet, F.; Fellmann, D.; Becque, O.; Techenet, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 172(6): 1114-1118
1978
ISSN/ISBN: 0037-9026 PMID: 159098 Document Number: 128956
In young male rats, long-term treatment with phenytoïn reduces the amount of calcium and magnesium in the femurs and provokes a stimulation of the parathyroiïds witnessed by the hypertrophy and hyperplasy of the parathyroid cells. Neither plasma calcium nor plasma and erythrocyte magnesium are modified.
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