The effect of the long-term treatment with calcium antagonists on myocardial function in patients with hypertension
Svishchenko, E.P.; Korchinskaia, O.I.; Stroganova, N.P.; Radchenko, V.V.
Likars'ka Sprava 1992(11-12): 77-80
1992
ISSN/ISBN: 1019-5297 PMID: 1292230 Document Number: 396932
Prolonged effect (6-12 months) of verapamil and nifedipine on the systolic and diastolic function of the myocardium was studied in 48 patients with hypertensive disease (stage II). It was established that in patients with a high ejection fraction (55% and more) the two drugs produce a distinct reduction of the pumping heart function. The two drugs increase the rate of early diastolic filling. They also may reduce the arterial pressure via different hemodynamic mechanisms: vasodilatation or via reduction of cardiac output.