Determination of cytosine arabinoside in human plasma by high-pressure liquid chromatography
Bury, R.W.; Keary, P.J.
Journal of Chromatography 146(2): 350-353
1978
ISSN/ISBN: 0021-9673 PMID: 279543 Document Number: 125766
Blood samples from 6 leukemic patients receiving constant i.v. infusions of ara-C over 7 days were taken twice between days 2 and 7 to determine the plasma levels likely to be obtained in a steady-state situation. There was no apparent correlation between the dose of ara-C administered daily and the plasma concentration attained in these patients. This was probably a reflection of pharmacokinetic variability and emphasized the difficulties in establishing appropriate dosage schedules. Routine measurement of ara-C in plasma may prove useful in this regard.