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Effect of meproscillarin on left ventricular hemodynamics

Pachinger, O.; Probst, P.

Arzneimittel-Forschung 28(3a): 550-552

1978

ISSN/ISBN: 0004-4172
PMID: 580587
Document Number: 125034
In 10 patients with angiographically proven coronary artery disease we investigated the influence of the glycoside 14-hydroxy-3beta-[(4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin, Clift) on left ventricular performance with invasive methods. After a single i.v. bolus injection a decrease in left ventricular end-diastolic pressure associated with an increase of the maximum rate of pressure rise (dp/dtmax) and left ventricular pressure (LVP) was observed. These changes were not accompanied by significant alterations of the heart rate during an observation period of 60 min.

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