Ultrastructural study of rat liver after administration of an aminated steroid
Choppin, J.; Vu-Ngoc-Huyen; Desplaces, A.
Pathologie-Biologie 26(7): 405-410
1978
ISSN/ISBN: 0369-8114 PMID: 372895 Document Number: 125033
The administration of amino-3 beta hydroxy-20 beta pregnene-5, to the male Wistar rat, per os, at doses of 100 and 200 mg/kg/24 h, induce the development of a chronic active hepatitis. The ultrastructural observation shows slight changes only in perilobular hepatocytes at the beginning of treatment; then hepatocellular alterations progressively increase and may be observed in the whole lobule after 40 and 80 days of treatment; the progression of hepatocellular damage is associated with collagen increase and bile duct proliferation. The interest of this experimental hepatitis, as a model analogous to human chronic active hepatitis, is discussed.