Ultrastructural study of the different zones of the rat liver acinus after portacaval anastomosis
Bioulac, P.; Dubuisson, L.; Saric, J.; Balabaud, C.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 173(1): 60-67
1979
ISSN/ISBN: 0037-9026 PMID: 158419 Document Number: 150304
Liver atrophy is a main feature in rats with a porto caval shunt. Histological studies revealed small size hepatocytes. Ultrastructural differences between periportal and centrolobular zones were noticed, in particular, the dilatation of the nuclear envelope and of the rough endoplasmic reticulum which appeared dilated, desorganized and sometimes without ribosomes, was more pronounced in the periportal zone. Hepatocytes of this zone might be more sensitive to the decrease of O2 and/or hepatotrophic factors.