Ultrastructural study of the liver in rabbits treated with diclofenac
Butturini, L.; Boiardi, L.; Menozzi, I.; Bernardi, S.; Restori, G.; Martines, G.
Revista de Medicina de la Universidad de Navarra 31(1): 11-13
1987
ISSN/ISBN: 0556-6177 PMID: 3616358 Document Number: 303742
The existence of alterations of common indexes of hepatic function, and the case-reports of acute hepatitis after the use of diclofenac sodium are the rationale for this experimental study, in which 8 rabbits were given 15 mg/kg day of diclofenac, to check ultrastructural modifications with respect to a control group. The analysis showed the typical signs of primary and secondary microcholestasis, indicating the existence of liver distress. This finding, from a clinical standpoint, suggests caution in the administration of this drug, chiefly in the hepatopathic patients.