Irritation of gastrointestinal mucosa by new glycosyl derivative of diclofenac in comparison with diclofenac in rats
Borowiecka, J.; Pakulska, W.; Graczyk, J.; Wagrowska-Danilewicz, M.
Acta Poloniae Pharmaceutica 57 Suppl: 99-102
2000
ISSN/ISBN: 0001-6837 PMID: 11293281 Document Number: 515785
We have obtained new glycosyl derivative of diclofenac 3 and studied its ulcerogenic effect in the gastrointestinal system. Diclofenac as free acid 1 and its derivative 3 were administered to rats per os in a single dose 20 mg/kg and in 5 doses of 5 mg/kg. Single dose of derivative 3 caused less irritation than 1; after multiple administration no irritating effect of derivative 3 was seen.
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