Effects of 6,7-dimethoxycoumarin on left ventricular function and hemodynamics in anesthetized cats
Huang, J.C.; Wang, X.R.; Sun, A.X.
Zhongguo Yao Li Xue Bao 14(3): 253-256
1993
ISSN/ISBN: 0253-9756 PMID: 8237404 Document Number: 416593
Scoparone (6, 7-dimethoxycoumarin 1.25, 2.5, 5 mg cntdot kg-1) influenced the cardiohemodynamic functions in anesthetized cats. After iv injection the LVP-dP/dt loops and blood pressure were decreased. Both the contractile and relaxant functions of the left ventricle were inhibited. These were demonstrated by the reduction of dP/dt-max, V-ce-dp40, LVSP, prolongation of LVET, diminution of -dP/dt-max, and extension of the constant time of isometric diastolic pressure decay (T value). The preload of the left ventricle, LVEDF, was raised and the afterload (MAP, TPB) was decreased. The systolic volume, systolic index, cardiac output, and cardiac index were decreased slightly. The parameters TTI and TTI times HR, which reflect the myocardial oxygen consumption, were reduced. Furthermore, the heart rate was decreased at 5 mg cntdot kg-1. The results indicate that scoparone could suppress the myocardial activity.