Effects of fentanyl on left ventricular diastolic function
Tamura, T.
Masui. Japanese Journal of Anesthesiology 38(10): 1282-1292
1989
ISSN/ISBN: 0021-4892 PMID: 2585697 Document Number: 342998
Effects of fentanyl on left ventricular diastolic function were investigated in chronically instrumented dogs. An electromagnetic mitral flow probe was placed in the left atrium and a micromanometer was placed in the left atrium as well as in the left ventricle to measure ventricular pressure (LVP), left atrial pressure (LAP), derivative of left ventricular pressue (dp/dt), mitral flow (MIF) and ECG in conscious resting dogs. Following induction of anesthesia with thiopental (15 .apprx. 20 mg .cntdot. kg-1) and vecuronium (0.1 mg .cntdot. kg-1), fentanyl (10, 50 and 100 mcg .cntdot. kg-1) was administered at 30 min intervals. The direct measurement of phasic MIF was used to obtain a set of diastolic indices: peak rapid filling period (PRFR), filling volume (FV), FV due to atrial contraction (FV-A), isovolumic relaxation period (IVRP) and diastolic filling period (DFP). Each diastolic index during conscious resting state was compared with that obtained during fentanyl anesthesia using paired t-test. There were no significant changes in those diastolic indices under fentanyl (10, 50 and 100 mcg .cntdot. kg-1) anesthesia except PRFR and dp/dt under fentanyl 10 mcg .cntdot. kg-1 which decreased. Although heart rate decreased about 50% under fentanyl, IVRP and PRFR did not increase significantly, but DFP (P < 0.05) and FV (P < 0.01) increased significantly. DFP correlated well with RR interval under conscious resting state under fentanyl anesthesia (r = 0.992 and r = 0.967). This study suggests that in the absence of surgical stress, fentanyl does not impair left ventricular diastolic function.