Effects of Poly A. Poly U in vivo alterations of proportions of T and B cell subsets
Donner, M.; Bischoff, P.; Lacour, F.
Developments in Biological Standardization 38: 159-165
1977
ISSN/ISBN: 0301-5149 PMID: 305372 Document Number: 120653
Spleens and thymuses of mice were examined for changes in lymphocyte subpopulations after in vivo treatment with a double stranded synthetic polynucleotide: Poly A.Poly U. The cell populations were characterized on a biophysical basis: the electrical charge of cell surface assessed by the anodic electrophoretic mobility. The proportion of spleen cells exhibiting a high electrophoretic mobility (T lymphocytes) increased markedly on the 3rd day after a single intravenous injection of Poly A.Poly U. In thymuses, early important variations in electrophoretic distribution profiles were observed after Poly A.Poly U injection, suggesting that adjuvant acts on T cells.