Integration of lipid utilization with Krebs cycle activity in muscle
Hochachka, P.W.; Neely, J.R.; Driedzic, W.R.
Federation Proceedings 36(7): 2009-2014
1977
ISSN/ISBN: 0014-9446 PMID: 193739 Document Number: 119901
Ways in which beta -oxidation and the citric acid cycle interact are illustrated; these include competition for CoASH, competition for NAD+ and competition for FADH2 oxidation, by which the cell is able to maintain a precise coordination between the activation of fatty acids in cytosol, beta -oxidation in mitochondria and complete oxidation of acetyl-CoA to CO2 through the citric acid cycle over a wide range of energy demands and oxygen availability.