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Oxidative phosphorylation of Krebs cycle substrates in experimental treatment of enterocolitis with cytochrome c

Khadzhiev, K.K.; Chirko, I.G.

Voprosy Meditsinskoi Khimii 26(2): 154-157

1980

ISSN/ISBN: 0042-8809
PMID: 6256954
Document Number: 155617
After administration of exogenous cytochrome c into rats with enterocolitis, caused by salmonellae, tissue respiration and oxidative phosphorylation in presence of succinic, alpha-ketoglutaric, pyruvic and oxaloacetic acids were increased in the liver tissue. Treatment with cytochrome c produced a positive effect on the general state of an organism, led to disappearance of macroscopic alterations in mucosa of small intestine. The data obtained suggest that cytochrome c possesses the positive therapeutic effects in enterocolitis caused by salmonellae.

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