The general pharmacological actions of KW-1062, a new aminoglycoside antibiotic
Hashimoto, T.; Ichikawa, S.; Kojima, T.
Japanese Journal of Antibiotics 30(6): 362-385
1977
ISSN/ISBN: 0368-2781 PMID: 894835 Document Number: 112688
The general pharmacological actions of KW-1062 were investigated in order to estimate the effects on the host animals. KW-1062 showed little or no effect on the central nervous system, cardiovascular system, smooth muscle, skeletal muscle, hemolysis, blood coagulation, dermal tissue permeability and antigenicity tests at high doses. KW-1062 showed urinative effect and ototoxicity. But ototoxicity of KW-1062 was less potent than that of gentamicin. KW-1062 has been proved to have a safety margin wider than that of other aminoglycoside antibiotics.