Clinical experience with amikacin, a new aminoglycoside antibiotic
Theron, F.P.; De Kock, M.A.
South African Medical Journal 51(21): 746-748
1977
ISSN/ISBN: 0256-9574 PMID: 327583 Document Number: 118064
Amikacin, a new semisynthetic aminoglycoside antibiotic, was administered parenterally to 20 patients suffering from severe Gram-negative bacterial infections. The antibiotic was found to be highly effective in controlling infection. It was well tolerated and no signs of nephro- or otoxicity were observed. The few side-effects which were seen appeared to be dose-related. The recommended 12-hourly dosage regimen has also proved useful in medium- to long-term management of refractory pulmonary infections.