Pharmacokinetic and clinical research on a new aminoglycoside antibiotic: sisomicin
Di Nola, F.; Soranzo, M.L.; Bosio, G.; Sachelariu, N.; Guasco, C.; Bendiscioli, L.; Bisarello, I.
Minerva Medica 69(43): 2951-2962
1978
ISSN/ISBN: 0026-4806 PMID: 714275 Document Number: 138478
Results obtained with sisomycin in 10 cases of purulent meningitis and 4 of bronchopulmonitis showed good tissue diffusion, together with CSF concentrations sufficient to inhibit the main aetiological agents in these forms: MIC 0.02 mg/ml for both D. pneumoniae (I-ATCC 6301) and N. meningitidis (C-ATCC 13101), i.e. liquor transfer of the antibiotic more than sufficient to handle these agents.
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