Clinical experience of sisomicin sulfate by intravenous drip infusion for the treatment of infection complicated by malignant disease
Tamura, K.; Araki, Y.; Amamoto, T.; Seita, M.
Japanese Journal of Antibiotics 37(7): 1237-1240
1984
ISSN/ISBN: 0368-2781 PMID: 6593472 Document Number: 223049
Sisomicin sulfate (SISO) was used for the treatment of infections complicated by malignant diseases in 10 cases; 4 cases with suspicious sepsis; 2 with pneumonia; 2 with urinary tract infection; 1 with renal abscess; and 1 with cholecystitis. SISO was administered by i.v. drip infusion at daily dose from 100-150 mg for 6-12 days, concomitantly with other antibiotics. Clinical results were as follows; good in 2; fair in 5; and poor in 3 cases. As to the side effects of SISO, cylindruria with aggravation of microscopic hematuria and elevations of GOT were observed in each of them, respectively. The relationship to the SISO was not clear. The drip infusion of SISO may be useful for the treatment of serious infection complicated by malignant diseases.