Large-scale screening of mtDNA A1555G mutation in China and its significance in prevention of aminoglycoside antibiotic induced deafness
Liu, X.; Dai, P.; Huang, D-liang.; Yuan, H-jun.; Li, W-min.; Cao, J-yang.; Yu, F.; Zhang, R-ning.; Lin, H-yan.; Zhu, X-hui.; He, Y.; Yu, Y-jun.; Yao, K.
Zhonghua Yi Xue Za Zhi 86(19): 1318-1322
2006
ISSN/ISBN: 0376-2491 PMID: 16796900 Document Number: 599516
To explore the necessity of large-scale screening of mtDNA A1555G mutation in prevention of aminoglycoside antibiotic induced deafness (AAID) and to develop a feasible method to prevent AAID. A total of 1836 patients with non-syndromic hearing impairment (NSHI), 1352 students of schools for deaf-mutes in 11 provinces and municipality in China, 413 out-patients, and 71 persons from the families with maternal relatives suffering from AAID, underwent questionnaire survey and/or PCR for A-to-G mutation at nucleotide 1555 of the mitochondrial genome. Sixty three patients with mtDNA A1555G mutation were found among the 1836 NSHI patients. Fifty-two maternal pedigrees were identified. 536 cases with normal hearing from these pedigrees were informed to avoid using aminoglycoside antibiotics (AmAn). Large-scale screening of mtDNA A1555G mutation and relevant health education to avoid use of AmAn are effective to prevent ototoxicity in the A1555G carriers and their maternal relatives.