Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals
Priestly, B.G.; Plaa, G.L.
Archives Internationales de Pharmacodynamie et de Therapie 223(1): 132-141
1976
ISSN/ISBN: 0003-9780 PMID: 999392 Document Number: 105662
Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 wk; 25 mg/l in drinking water for 2-3 mo.) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic transaminase or serum alkaline phosphatase activities. Neither acute nor subchronic administration modified the hepatotoxic response to a potent hepatotoxin (carbon tetrachloride), nor that of less potent hepatotoxins chloroform or 1, 1, 1-trichloroethane, nor was the cholestatic effect of .alpha.-naphthylisothiocyanate modified.