Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies
Kandarkar, S.V.; Sawant, S.S.; Ingle, A.D.; Deshpande, S.S.; Maru, G.B.
Indian Journal of Experimental Biology 36(7): 675-679
1998
ISSN/ISBN: 0019-5189 PMID: 9782784 Document Number: 490488
Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.