Lovastatin-acetaminophen subchronic toxicity in mice
Raje, R.R.; Bhattacharya, S.
Research Communications in Chemical Pathology and Pharmacology 69(3): 373-376
1990
ISSN/ISBN: 0034-5164 PMID: 2236904 Document Number: 355010
A subchronic, toxicity study of lovastatin-acetaminophen combination in s/w mice is reported. Oral administration of lovastatin in corn oil 30 mg/kg three times a week and acetaminophen 0.75% w/v in drinking water for 13 weeks resulted in significant increase in SGPT (ALT) in both male and female mice. Histopathology of the liver revealed centrilobular hepatocyte swelling. These results provide evidence of hepatic injury in s/w mice when concomitantly exposed to lovastatin and acetaminophen.