Influence of age and sex on hepatotoxic and hypothermic effects of estrogole in mice
Kaledin, V.I.; Vasil'eva, E.D.; Il'nitskaia, S.I.; Morozkova, T.S.; Amstislavskaia, T.G.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 93(8): 844-851
2007
ISSN/ISBN: 0869-8139 PMID: 17926915 Document Number: 609957
Some physiological effects of estragole under a single intraperitoneal injection in oil solution were studied in GR mice; elevation of blood aminotransferases activity, body temperature and animals lethality were registered. At a dose of 600 mg/kg, estragole killed 100% sucklings of both sexes and 90% adult females but no any adult male. The males aquire resistance to estragole at the time of maturation. Exogenous testosterone administered at the dose of 50 mg/kg 4-2 days earlier increases the resistance of female mice to estragole up to its level in males. However, neonatally androgenized females are as sensitive to the toxic action of estragole as the males. At the dose of 900 mg/kg, estragole defeats adult males as well: significant elevation of aminotransferase activities in their blood is indicative of this. In this case, the enzyme activity reaches its peak after 2-3 days, not at the 1st day as in the case of carbon tetrachloride administration. We have discovered a strong hypothermic effect of estragole which appears to be unrelated to its hepatotoxicity and testosteron level.