The role of disruption of lipid metabolism in mechanisms of the hepatotoxic effects of cisplatin
Vetoshkina, T.V.; Dubskaia, T.I.
Voprosy Meditsinskoi Khimii 39(6): 23-26
1993
ISSN/ISBN: 0042-8809 PMID: 8303866 Document Number: 414411
Distinct alterations in the metabolism of lipids and phospholipids as well as activation of lipid peroxidation in liver tissue were detected in mice after administration of a new antitumoral drug cisplatin at a dose of LD50 (13.5 mg/kg) or after the course treatment within 5 days using 1/5 LD50. Content of malonic dialdehyde, diene conjugates and Schiff bases was increased, while the phospholipid composition was altered and concentration of membrane-toxic ingredients was increased. When the effects of cisplatin, administered at a dose of LD50 and during the course treatment, were analyzed more pronounced impairments of lipid metabolism were found during 7-15 days in mice treated with the drug at LD50. However, the drug toxic effect was manifested earlier during the course of treatment and in some cases it maintained for a long time (up to 30 days of the experiment). The data obtained suggest that correction of the cytostatic-induced impairments in liver tissue functions may be carried out by means of the anti-radical drugs.