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Action of isopropanol on rat lipid metabolism: complementary studies on mechanisms implicated in hepatic accumulation of triacylglycerides

Beaugé, F.; Clément, M.; Renaud, G.; Nordmann, R.; Nordmann, J.

Archives Internationales de Physiologie et de Biochimie 83(3): 573-591

1975

ISSN/ISBN: 0003-9799
PMID: 54136
Document Number: 90152
Isopropanol administration (3 g/kg, p.o.) determines in the rat liver an inhibition of fatty acid oxidation, an enhancement of fatty acid esterification into triacylglycerols as well as an inhibition of lipoprotein secretion which appears to be related to alterations in hepatic phospholipids and which differentiates isopropanol from ethanol induced fatty liver. Disturbances in peripheral lipolysis following isopropanol administration are found only in mature rats and are not necessary to the fatty liver induction.

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