Cell modulation in the regenerating liver following partial hepatectomy: an autoradiographic study
Sengupta, P.
Indian Journal of Medical Research 64(5): 680-687
1976
ISSN/ISBN: 0019-5340 PMID: 965069 Document Number: 104893
The regeneration of liver between 48 and 288 h following partial hepatectomy when about 60% of the lost cell mass was restored, was studied in Wistar rats. The pattern of the cellular proliferation was assessed by autoradiographic technique using tritiated thymidine. The cellular activity during regeneration followed a cyclic order. In the initial phase there was marked proliferation of both parenchymal and mesenchymal cells, followed by a midphase of active proliferation of ductular cell, terminating in a final phase of rebound increased proliferative activity of both parenchymal and mesenchymal cells. The rapid initial restoration of liver cell mass along with proliferation of mesenchymal cell and relatively delayed development of bile duct system were noteworthy. Cellular modulation in the regenerating liver between 48-288 h following partial hepatectomy, leading to restoration of liver cell plates and subsequently the development of the bile duct system was largely dependent on the sustained activity of mesenchymal elements along with an early proliferation of parenchymal cells.