Studies on liver regeneration. Deoxyribonucleic acid synthesis in the isolated perfused liver after in vitro and in vivo partial hepatectomy
Grandjean, C.; Garcia, H.
Laboratory Investigation; a Journal of Technical Methods and Pathology 32(4): 552-554
1975
ISSN/ISBN: 0023-6837 PMID: 1127874 Document Number: 91307
A new method for studying liver regeneration has been introduced. In the isolated perfused liver partial hepatectomy has been performed and -3H-thymidine incorporation into DNA was observed. The short term incorporation observed in vitro was comparable to that observed in vivo under similar conditions. The results suggest that similar regenerative mechanisms are operating in vivo and in vitro, and that the liver is at least one source of the regenerating stimuli.