Synthesis of pteroylpolyglutamates in rat liver during regeneration after partial hepatectomy
Tolomelli, B.; Bovina, C.; Formiggini, G.; Marchetti, M.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 50(4): 412-415
1980
ISSN/ISBN: 0300-9831 PMID: 7203853 Document Number: 155509
The liver content of higher polyglutamate forms of folic acid, which in partially hepatectomized rats is markedly lower as compared with sham operated animals, is normalized by the vitamin administration. The greater availability of folic acid and consequently of the tetrahydrofolates, promotes the synthesis of actual coenzymic forms; so their content, in regenerating liver, is maintained at normal values in spite of a higher requirement caused by the exaltation of biosynthetic processes.