Dynamics of the development of oval cell population induced in the liver by dipin and partial hepatectomy
Radaeva (Pronina), S.A.; Faktor, V.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 109(5): 514-517
1990
ISSN/ISBN: 0365-9615 PMID: 2378977 Document Number: 365766
It has been shown that dipin in combination with partial hepatectomy (model of dipin hepato-carcinogenesis) induces massive oval cell proliferation. The main stages of oval cells development examined by means of light microscopy of half-thin slices are the following: 1) appearance around portal tracts--1-3 weeks; 2) migration into parenchyma along terminal branches of portal vessels--3-8 weeks; 3) maximum development--8-10 weeks; 4) induction focuses of growth of new formed hepatocytes around portal tracts--8-10 weeks; 5) forcing of oval cells towards the centre of liver lobules and their elimination. There was close correlation between oval cells development, fibrosis and inflammation. Oval cells remained around portal tracts until the development of numerous hepatomas in 10 months after treatment.