Modulation of ornithine decarboxylase activity in the normal and regenerating rat liver by different doses of hydra peptide morphogen
Iarygin, K.N.; Kazimirskiĭ, A.N.; Kositskiĭ, G.I.; Rubina, A.I.; Vinogradov, V.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(6): 680-682
1986
ISSN/ISBN: 0365-9615 PMID: 3730551 Document Number: 280765
The authors studied the anabolic effect of peptide morphogen of the hydra undecapeptide on normal and regenerating rat liver. Ornithine decarboxylase (EC 4.1.1.17) activity served as a marker. Intraperitoneal injection of the peptide into intact animals stimulated ornithine decarboxylase activity in a dose-dependent manner. In partially hepatectomized rats the peptide stimulated ornithine decarboxylase activity in the dose of 20 micrograms/kg body weight while greater doses inhibited the enzyme activity.