Relationship of cholesterogenesis to plasma membrane cholesterol modulation during the first cell cycle after partial hepatectomy in the rat
Leoni, S.; Spagnuolo, S.; Mangiantini, M.T.; Trentalance, A.
Cellular and Molecular Biology 28(1): 131-134
1982
ISSN/ISBN: 0145-5680 PMID: 7083274 Document Number: 191552
Cholesterol synthesis and microsomal 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCoA reductase) activity in rat liver at different times of the first cell cycle after partial hepatectomy were studied. The decreased cholesterol synthesis at the onset of the S phase could be responsible for the lower plasma membrane cholesterol/phospholipid ratio previously reported; the observed inverse patterns of HMGCoA reductase activity and cholesterol synthesis appear to be very interesting.